Sydney Pollack, a Hollywood mainstay as director, producer and sometime actor whose star-laden movies like “The Way We Were,” “Tootsie” and “Out of Africa” were among the most successful of the 1970s and ’80s, died at home at 73. The cause was cancer.

Mr. Pollack’s career defined an era in which big stars (Robert Redford, Barbra Streisand, Warren Beatty) and the filmmakers who knew how to wrangle them (Barry Levinson, Mike Nichols) retooled the Hollywood system. Savvy operators, they played studio against studio, staking their fortunes on pictures that served commerce without wholly abandoning art.

Hollywood honored Mr. Pollack in return. His movies received multiple Academy Award nominations, and as a director he won an Oscar for his work on the 1985 film “Out of Africa” as well as nominations for directing “They Shoot Horses, Don’t They?” (1969) and “Tootsie” (1982).

“Michael Clayton,” of which Mr. Pollack was a producer and a member of the cast, was nominated for a best picture Oscar earlier this year. He delivered a trademark performance as an old-bull lawyer who demands dark deeds from a subordinate, played by George Clooney. (“This is news? This case has reeked from Day 1!” snaps Mr. Pollack’s Marty Bach.) Most recently, Mr. Pollack portrayed the father of Patrick Dempsey’s character in “Made of Honor.”